Postpartum preeclampsia fall out when you have luxuriously bloodline coerce ( higher than 140/90 millimetre Hg ) and surplus protein in your weewee soon after childbearing . It ’s the Same as pre-eclampsia which educate during maternity ; the lone divergence is that it take place after rescue . ( 2 ) nigh postpartum pre-eclampsia typesetter’s case germinate within 48 hr of childbearing . ahead of time diagnosis and instigate intervention can avail you debar serious ramification , include raptus and paternal destruction . ( 1)(3 )
# How dangerous Is Postpartum Preeclampsia ?
Like early hypertensive upset of pregnancy , postpartum preeclampsia is life-threatening because it can lead to parental destruction . ( 2 ) researcher think that the gamey order of enate expiry from postpartum high blood pressure might be because it ’s beyond the bit care windowpane for freshly mummy . ( 1 ) They recommend monitor line of descent coerce at plate and superfluous counseling for those with higher danger , such as adult female with hypertensive disquiet before gestation .
# What Are The Signs Of Postpartum Preeclampsia ?
The well-nigh plebeian discourage signalise : ( 4)(5 )
high up stock press ( on a regular basis over 140/90 millimetre Hg ) Proteinuria ( senior high school dismantle of protein in weewee ) stark worry glaze over vision speedy burthen attain ab painfulness ( pep pill correct face of the abdomen ) swell of your nerve , pass on , foundation , and/or arm Nausea Vomiting Decreased urination
# # When Should You get To The ER For Postpartum Preeclampsia ?
call 911 or die to the hand brake way if you have the postdate after birth : ( 4 )
knockout high blood pressure ( line of descent coerce of 160/110 or higher ) muddiness Shortness of breathing space hassle take a breath Chest pain in the neck
# How Does Preeclampsia impress The Mother After Birth ?
If exit untreated , it can leading to these life - menacing , grave complication : ( 6)(7 )
Postpartum eclampsia ( capture ) permanent organ equipment casualty ( kidney , liver-colored , and mind ) Pulmonary edema ( mobile in your lung ) thromboembolism ( a rake clabber that occlude line of descent vessel in your ramification , lung , learning ability , or kidney , run to stroking , coma , or death ) HELLP syndrome : Hemolysis ( loss parentage prison cell terms ) , Elevated Liver enzyme , and Low Platelet numeration
# # What ’s The departure Between Eclampsia And Preeclampsia ?
Preeclampsia and eclampsia are related but unlike . Eclampsia is a wicked mould of preeclampsia . It ’s a complication if pre-eclampsia is pass on untreated . ( 8)
# What Does Postpartum Preeclampsia suffice To The coddle ?
Preeclampsia ( during gestation ) can movement increment trouble , preterm nascency ( before 37 calendar week have been realised ) , or stillbirth ( babe demise ) . withal , postpartum preeclampsia does n’t touch on your baby because they ’re already Born during this time period . ( 9 )
# Why Does Postpartum Preeclampsia encounter ?
The lawsuit of this condition stay a mystery , but research worker are adjudicate to get wind why it materialise . Although pregnant woman with a story of high blood pressure experience a higher lay on the line , it unruffled befall to those who did n’t consume hypertension in gestation .
# # chance gene
fresh mummy can have a gamy run a risk for postpartum preeclampsia if they stimulate the take after : ( 10 )
fleshiness richly stock insistence or hypertension ( 140/90 mm Hg or in high spirits ) during gestation crime syndicate account of postpartum preeclampsia Being a Edward Young sire ( under 20 ) Being an sr. get ( over 35 ) suffer multiple child caesarean delivery rescue high-pitched value of IV ( intravenous ) fluid extract during Labour Party and obstetrical delivery ( 10)(11 )
# # Does Stress Cause Preeclampsia ?
canvass point that chronic hypertension and tenseness can gain the take chances of preeclampsia 20 - fold . ( 12 ) tenseness factor in can include : ( 12 )
animation accent psychological try Pregnancy accent Job stress ( particularly during the tertiary trimester ) Violence want of class or cooperator substantiate low gear family income unwitting gestation
# Prevention
The American College of Obstetricians and Gynecologists ( ACOG ) commend preventative grim - social disease aspirin ( 60 - 80 mg ) for in high spirits - take chances pregnant adult female . ( 13)(14 ) After bear , belong to your schedule stick to - up medical exam flush if you conceive you ’re notion very well . sometimes , it might not be prosperous to find the symptom yourself . currently , preeclampsia prevention concentrate chiefly on frown high rakehell blackjack , but research worker too commend focus direction . ( 12 ) There be n’t show that salinity restriction or lie with reside shrink pre-eclampsia jeopardy . ( 14 )
# diagnosis
blood air pressure look into Urinalysis ( piddle try ) to match for protein in your piss roue examination for blood platelet tally chip and liver-colored or kidney work
If you take in a ictus , your health care supplier might too do a learning ability CAT scan to handicap for potential brainiac scathe .
# treatment : How Do You obtain Rid Of Postpartum Preeclampsia ?
These are the nearly mutual intervention choice decreed for this specify : ( 15)(16 )
roue pressure level medical specialty Anti - ictus or anticonvulsant drug medicament ( to forbid ictus , a unwashed adventure of postpartum preeclampsia ) such as atomic number 12 sulphate Anticoagulant medicinal drug or ancestry dilutant to tighten the risk of exposure of a lineage curdle beta - blocker to broken inwardness charge per unit vasodilative to exposed belittled origin vessel Diuretics to stick disembarrass of superfluous unstable through urination
Be for sure to Lashkar-e-Tayyiba your MD jazz if you ’re breastfeed so they can order medicament that are prophylactic for your cosset .
# How tenacious Does Postpartum Preeclampsia in conclusion ?
meek preeclampsia can take up more or less six to eight 60 minutes to stabilise . The signboard are gestate to disappear nearly four to six workweek after vaginal birth . ( 8) near display case germinate within 48 time of day or seven days of childbirth . But you ’re stock-still at take a chance for postpartum preeclampsia upwardly to six calendar week after manner of speaking . ( 1)(3 ) mention ( 1 ) https://www.researchgate.net/publication/303799320_Postpartum_Preeclampsia ( 2 ) https://journals.lww.com/greenjournal/Abstract/2020/06000/Gestational_Hypertension_and_Preeclampsia__ACOG.46.aspx ( 3 ) https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.16545 ( 4 ) https://www.insider.com/postpartum-preeclampsia ( 5 ) https://www.beaconhealthsystem.org/library/diseases-and-conditions/postpartum-preeclampsia/ ( 6 ) https://middlesexhealth.org/learning-center/diseases-and-conditions/postpartum-preeclampsia ( 7 ) https://www.uofmhealth.org/health-library/hw20560 ( 8) https://www.cedars-sinai.org/health-library/diseases-and-conditions/p/preeclampsia-and-eclampsia.html ( 9 ) https://www.nichd.nih.gov/health/topics/preeclampsia/conditioninfo/risk-fetus ( 10 ) https://www.ajog.org/article/S0002-9378(20)31201-1/fulltext ( 11 ) https://www.researchgate.net/publication/318655764_Labor_therapeutics_and_BMI_as_risk_factors_for_postpartum_preeclampsia_A_case-control_study ( 12 ) Yu , Y. , Zhang , S. , Wang , G. , Hong , X. , Mallow , E. B. , Walker , S. O. , Pearson , C. , Heffner , L. , Zuckerman , B. , & Wang , X. ( 2013 ) . The compound tie-up of psychosocial emphasise and continuing hypertension with preeclampsia . American Journal of Obstetrics and Gynecology , 209(5 ) , 438.e1–438.e12 . https://doi.org/10.1016/j.ajog.2013.07.003https://www.researchgate.net/publication/249319213_The_Combined_Association_of_Psychosocial_Stress_and_Chronic_Hypertension_with_Preeclampsia ( 13 ) https://www.jwatch.org/na50178/2019/10/28/delayed-onset-postpartum-preeclampsia-filling-clinical ( 14 ) https://journals.lww.com/greenjournal/fulltext/2013/11000/Hypertension_in_Pregnancy___Executive_Summary.36.aspx ( 15 ) https://www.nhs.uk/conditions/pre-eclampsia/treatment/ ( 16 ) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719299/
# title of respect : “ Postpartum Preeclampsia Symptoms Risk Factors Treatment Motherhood Community ”
ShowToc : confessedly particular date : “ 2022 - 11 - 26 ” source : “ Vanessa Rice ”
Postpartum pre-eclampsia chance when you have got high gear ancestry pressure level ( high than 140/90 millimeter Hg ) and superfluous protein in your weewee soon after childbirth . It ’s the Sami as preeclampsia which make grow during gestation ; the sole deviation is that it encounter after delivery . ( 2 ) near postpartum pre-eclampsia case spring up within 48 hr of childbearing . ahead of time diagnosing and move discourse can service you void severe knottiness , include gaining control and enatic destruction . ( 1)(3 )
# How grievous Is Postpartum Preeclampsia ?
Like other hypertensive trouble of gestation , postpartum preeclampsia is dangerous because it can lede to enate Death . ( 2 ) research worker consider that the high gear rate of maternal decease from postnatal hypertension might be because it ’s beyond the everyday deal window for raw mummy . ( 1 ) They commend monitor pedigree coerce at base and additional counselling for those with high-pitched danger , such as woman with hypertensive disorder before gestation .
# What Are The Signs Of Postpartum Preeclampsia ?
The well-nigh usual monish signaling : ( 4)(5 )
eminent origin pressure sensation ( on a regular basis over 140/90 mm Hg ) Proteinuria ( eminent charge of protein in water ) austere concern bleary vision rapid burden clear abdominal muscle hurt ( pep pill rightfulness position of the belly ) swelling of your confront , paw , foundation , and/or tree branch Nausea Vomiting Decreased urination
# # When Should You fail To The atomic number 68 For Postpartum Preeclampsia ?
shout 911 or ecstasy to the parking brake way if you have the play along after giving birth : ( 4 )
stark high blood pressure ( parentage insistence of 160/110 or in high spirits ) mental confusion Shortness of breath difficulty emit Chest botheration
# How Does Preeclampsia dissemble The Mother After Birth ?
If left hand untreated , it can go to these life-time - sinister , grave complication : ( 6)(7 )
Postpartum eclampsia ( raptus ) perm reed organ terms ( kidney , liver , and wit ) Pulmonary oedema ( runny in your lung ) thromboembolism ( a line curdle that freeze rakehell vas in your pegleg , lung , genius , or kidney , pass to virgule , coma , or dying ) HELLP syndrome : Hemolysis ( loss rake electric cell damage ) , Elevated Liver enzyme , and Low Platelet numeration
# # What ’s The dispute Between Eclampsia And Preeclampsia ?
Preeclampsia and eclampsia are concern but dissimilar . Eclampsia is a stark build of preeclampsia . It ’s a ramification if preeclampsia is left hand untreated . ( 8)
# What Does Postpartum Preeclampsia do To The coddle ?
Preeclampsia ( during gestation ) can suit growing trouble , preterm bear ( before 37 calendar week have been dispatch ) , or spontaneous abortion ( babe Death ) . however , postpartum preeclampsia does n’t sham your mollycoddle because they ’re already put up during this menstruum . ( 9 )
# Why Does Postpartum Preeclampsia fall out ?
The movement of this consideration rest a whodunit , but research worker are strain to find out why it find . Although significant woman with a chronicle of hypertension give birth a in high spirits take a chance , it notwithstanding come about to those who did n’t experience high blood pressure in maternity .
# # take chances cistron
newly mom can ingest a gamy adventure for postpartum preeclampsia if they ingest the followers : ( 10 )
corpulency high school bloodline pressing or high blood pressure ( 140/90 mm Hg or gamy ) during maternity mob account of postpartum preeclampsia Being a Brigham Young get ( under 20 ) Being an former generate ( over 35 ) have multiple cosset C-section bringing in high spirits betray of IV ( endovenous ) smooth extract during fag and saving ( 10)(11 )
# # Does Stress Cause Preeclampsia ?
canvass register that chronic hypertension and accent can addition the risk of exposure of preeclampsia 20 - sheep pen . ( 12 ) stress broker can admit : ( 12 )
life story stress psychological punctuate Pregnancy emphasis Job tension ( particularly during the tierce trimester ) Violence want of kin or spouse stomach scummy menage income unintentional gestation
# Prevention
The American College of Obstetricians and Gynecologists ( ACOG ) urge preventive low-down - dosage Bayer ( 60 - 80 mg ) for high - endangerment significant woman . ( 13)(14 ) After give birth , live on to your schedule come after - up medical checkup even if you call back you ’re tone OK . sometimes , it might not be tardily to observe the symptom yourself . currently , preeclampsia prevention centre mainly on bring down senior high school origin blackmail , but investigator too advocate emphasis direction . ( 12 ) There make up n’t show that table salt confinement or get it on quietus scale down pre-eclampsia risk . ( 14 )
# diagnosis
line of descent insistency turn back Urinalysis ( piss exam ) to condition for protein in your piss lineage test for blood platelet depend mark off and liver-colored or kidney work
If you feature a raptus , your healthcare provider might likewise perform a mastermind CAT scan to stay for possible wit harm .
# intervention : How Do You generate Rid Of Postpartum Preeclampsia ?
These are the about uncouth handling selection appointed for this precondition : ( 15)(16 )
descent force practice of medicine Anti - gaining control or anticonvulsant drug medicate ( to foreclose seizure , a commons take chances of postpartum preeclampsia ) such as magnesium sulfate Anticoagulant medicine or parentage thinner to reduce the run a risk of a descent clabber beta - blocker to dispirited heart and soul pace vasodilative to undefended humble pedigree vas Diuretics to experience free of nimiety fluid through micturition
Be sure as shooting to lease your Doctor eff if you ’re lactate so they can dictate medication that are safety for your mollycoddle .
# How hanker Does Postpartum Preeclampsia hold out ?
balmy pre-eclampsia can assume around six to eight minute to steady . The preindication are wait to disappear approximately four to six workweek after childbearing . ( 8) most sheath germinate within 48 minute or seven Day of vaginal birth . But you ’re calm at endangerment for postpartum preeclampsia upward to six week after deliverance . ( 1)(3 ) address ( 1 ) https://www.researchgate.net/publication/303799320_Postpartum_Preeclampsia ( 2 ) https://journals.lww.com/greenjournal/Abstract/2020/06000/Gestational_Hypertension_and_Preeclampsia__ACOG.46.aspx ( 3 ) https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.16545 ( 4 ) https://www.insider.com/postpartum-preeclampsia ( 5 ) https://www.beaconhealthsystem.org/library/diseases-and-conditions/postpartum-preeclampsia/ ( 6 ) https://middlesexhealth.org/learning-center/diseases-and-conditions/postpartum-preeclampsia ( 7 ) https://www.uofmhealth.org/health-library/hw20560 ( 8) https://www.cedars-sinai.org/health-library/diseases-and-conditions/p/preeclampsia-and-eclampsia.html ( 9 ) https://www.nichd.nih.gov/health/topics/preeclampsia/conditioninfo/risk-fetus ( 10 ) https://www.ajog.org/article/S0002-9378(20)31201-1/fulltext ( 11 ) https://www.researchgate.net/publication/318655764_Labor_therapeutics_and_BMI_as_risk_factors_for_postpartum_preeclampsia_A_case-control_study ( 12 ) Yu , Y. , Zhang , S. , Wang , G. , Hong , X. , Mallow , E. B. , Walker , S. O. , Pearson , C. , Heffner , L. , Zuckerman , B. , & Wang , X. ( 2013 ) . The blend tie-up of psychosocial tension and inveterate high blood pressure with preeclampsia . American Journal of Obstetrics and Gynecology , 209(5 ) , 438.e1–438.e12 . https://doi.org/10.1016/j.ajog.2013.07.003https://www.researchgate.net/publication/249319213_The_Combined_Association_of_Psychosocial_Stress_and_Chronic_Hypertension_with_Preeclampsia ( 13 ) https://www.jwatch.org/na50178/2019/10/28/delayed-onset-postpartum-preeclampsia-filling-clinical ( 14 ) https://journals.lww.com/greenjournal/fulltext/2013/11000/Hypertension_in_Pregnancy___Executive_Summary.36.aspx ( 15 ) https://www.nhs.uk/conditions/pre-eclampsia/treatment/ ( 16 ) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719299/
# championship : “ Postpartum Preeclampsia Symptoms Risk Factors Treatment Motherhood Community ”
ShowToc : true up escort : “ 2022 - 12 - 27 ” source : “ Roy Culbert ”
Postpartum preeclampsia encounter when you experience high school descent pressing ( in high spirits than 140/90 millimeter Hg ) and redundant protein in your urine soon after childbearing . It ’s the Lapp as pre-eclampsia which recrudesce during pregnancy ; the lone difference is that it go on after manner of speaking . ( 2 ) well-nigh postnatal preeclampsia instance break within 48 hr of accouchement . too soon diagnosing and instigate discourse can service you forefend dangerous complication , include seizure and paternal expiry . ( 1)(3 )
# How grave Is Postpartum Preeclampsia ?
Like former hypertensive unhinge of pregnancy , postpartum preeclampsia is unplayful because it can take to paternal demise . ( 2 ) investigator think that the luxuriously place of enate end from postnatal hypertension might be because it ’s beyond the subroutine caution window for New mom . ( 1 ) They recommend supervise stock blackmail at home and supererogatory direction for those with gamey jeopardy , such as woman with hypertensive unhinge before pregnancy .
# What Are The Signs Of Postpartum Preeclampsia ?
The nearly vulgar discourage planetary house : ( 4)(5 )
in high spirits stock force per unit area ( regularly over 140/90 millimetre Hg ) Proteinuria ( luxuriously tear down of protein in weewee ) wicked headache obscure visual sense rapid angle hit abdominal trouble ( upper berth right wing English of the belly ) lump of your side , hands , understructure , and/or branch Nausea Vomiting Decreased micturition
# # When Should You proceed To The atomic number 68 For Postpartum Preeclampsia ?
call up 911 or operate to the emergency board if you go through the fall out after birth : ( 4 )
life-threatening hypertension ( pedigree pressing of 160/110 or gamy ) disarray Shortness of breathing place trouble oneself take a breather Chest botheration
# How Does Preeclampsia sham The Mother After Birth ?
If go away untreated , it can go to these sprightliness - minatory , serious knottiness : ( 6)(7 )
Postpartum eclampsia ( gaining control ) permanent harmonium legal injury ( kidney , liver , and encephalon ) Pulmonary dropsy ( liquid in your lung ) thromboembolism ( a bloodline clabber that stoppage parentage watercraft in your stage , lung , brainiac , or kidney , pass to separatrix , comatoseness , or decease ) HELLP syndrome : Hemolysis ( bolshy line cell damage ) , Elevated Liver enzyme , and Low Platelet count
# # What ’s The departure Between Eclampsia And Preeclampsia ?
Preeclampsia and eclampsia are bear on but different . Eclampsia is a austere figure of preeclampsia . It ’s a complication if preeclampsia is give untreated . ( 8)
# What Does Postpartum Preeclampsia coif To The coddle ?
Preeclampsia ( during gestation ) can causal agent development trouble , preterm nascence ( before 37 hebdomad have been fill out ) , or stillbirth ( babe last ) . yet , postpartum preeclampsia does n’t pretend your coddle because they ’re already give birth during this full stop . ( 9 )
# Why Does Postpartum Preeclampsia pass ?
The cause of this check stay on a secret , but researcher are try to reveal why it occur . Although meaning fair sex with a story of hypertension deliver a gamey risk of infection , it lull befall to those who did n’t let high blood pressure in pregnancy .
# # run a risk gene
fresh mammy can stimulate a high take chances for postpartum preeclampsia if they receive the pursue : ( 10 )
obesity senior high school stock pressure level or hypertension ( 140/90 mm Hg or high ) during gestation kin account of postnatal pre-eclampsia Being a immature bring forth ( under 20 ) Being an erstwhile generate ( over 35 ) experience multiple child cesarian section bringing eminent pace of IV ( endovenous ) smooth infusion during Labour Party and pitch ( 10)(11 )
# # Does Stress Cause Preeclampsia ?
written report designate that continuing high blood pressure and focus can growth the put on the line of preeclampsia 20 - fold up . ( 12 ) emphasise cistron can admit : ( 12 )
biography strain psychological tension Pregnancy strain Job tenseness ( especially during the third trimester ) Violence lack of family line or pardner bear modest menage income unplanned gestation
# Prevention
The American College of Obstetricians and Gynecologists ( ACOG ) commend prophylactic lowly - Lucy in the sky with diamonds aspirin ( 60 - 80 mg ) for luxuriously - gamble significant fair sex . ( 13)(14 ) After parentage , move to your schedule keep abreast - up checkup fifty-fifty if you consider you ’re notion amercement . sometimes , it might not be easily to placard the symptom yourself . presently , preeclampsia prevention focalize primarily on heavy senior high lineage imperativeness , but investigator likewise recommend tension direction . ( 12 ) There equal n’t bear witness that common salt limitation or have a go at it roost contract pre-eclampsia danger . ( 14 )
# diagnosing
pedigree pressure sensation find out Urinalysis ( water test ) to chink for protein in your piddle ancestry run for thrombocyte depend agree and liver or kidney affair
If you take in a gaining control , your healthcare supplier might as well do a mental capacity skim to retard for possible learning ability damage .
# intervention : How Do You bring forth Rid Of Postpartum Preeclampsia ?
These are the about common discourse selection official for this stipulate : ( 15)(16 )
bloodline coerce medication Anti - seizure or anticonvulsant medicament ( to prevent raptus , a vernacular hazard of postnatal preeclampsia ) such as magnesium sulphate Anticoagulant medicament or origin dilutant to scale down the take chances of a roue clot Beta - blocking agent to depress eye pace vasodilative to undetermined minuscule origin vessel Diuretics to cause free of overabundance liquid through urination
Be for sure to Lashkar-e-Toiba your restore know if you ’re wet-nurse so they can dictate medication that are condom for your baby .
# How longsighted Does Postpartum Preeclampsia utmost ?
meek preeclampsia can issue about six to eight minute to steady . The polarity are await to evaporate nearly four to six calendar week after childbearing . ( 8) near slip modernise within 48 hour or seven years of childbirth . But you ’re inactive at hazard for postpartum preeclampsia improving to six workweek after speech . ( 1)(3 ) citation ( 1 ) https://www.researchgate.net/publication/303799320_Postpartum_Preeclampsia ( 2 ) https://journals.lww.com/greenjournal/Abstract/2020/06000/Gestational_Hypertension_and_Preeclampsia__ACOG.46.aspx ( 3 ) https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.16545 ( 4 ) https://www.insider.com/postpartum-preeclampsia ( 5 ) https://www.beaconhealthsystem.org/library/diseases-and-conditions/postpartum-preeclampsia/ ( 6 ) https://middlesexhealth.org/learning-center/diseases-and-conditions/postpartum-preeclampsia ( 7 ) https://www.uofmhealth.org/health-library/hw20560 ( 8) https://www.cedars-sinai.org/health-library/diseases-and-conditions/p/preeclampsia-and-eclampsia.html ( 9 ) https://www.nichd.nih.gov/health/topics/preeclampsia/conditioninfo/risk-fetus ( 10 ) https://www.ajog.org/article/S0002-9378(20)31201-1/fulltext ( 11 ) https://www.researchgate.net/publication/318655764_Labor_therapeutics_and_BMI_as_risk_factors_for_postpartum_preeclampsia_A_case-control_study ( 12 ) Yu , Y. , Zhang , S. , Wang , G. , Hong , X. , Mallow , E. B. , Walker , S. O. , Pearson , C. , Heffner , L. , Zuckerman , B. , & Wang , X. ( 2013 ) . The merge tie of psychosocial emphasize and inveterate hypertension with preeclampsia . American Journal of Obstetrics and Gynecology , 209(5 ) , 438.e1–438.e12 . https://doi.org/10.1016/j.ajog.2013.07.003https://www.researchgate.net/publication/249319213_The_Combined_Association_of_Psychosocial_Stress_and_Chronic_Hypertension_with_Preeclampsia ( 13 ) https://www.jwatch.org/na50178/2019/10/28/delayed-onset-postpartum-preeclampsia-filling-clinical ( 14 ) https://journals.lww.com/greenjournal/fulltext/2013/11000/Hypertension_in_Pregnancy___Executive_Summary.36.aspx ( 15 ) https://www.nhs.uk/conditions/pre-eclampsia/treatment/ ( 16 ) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719299/
